Role Summary
The Chemical Process and Analytical Development (CPAD) group in Bothell WA develops innovative and phaseappropriate synthetic routes and scalable chemical processes for novel small molecule components for use in targeted therapeutics. Our process chemists analytical scientists and chemical engineers collaborate to design robust safe and scalable chemistry that accelerates delivery of lifechanging therapeutics to patients. As a Senior Principal Scientist in Process Chemistry you will serve as a key technical leader driving route scouting synthetic design process development and process characterization for our expanding portfolio. You will apply a strong foundation in modern synthetic organic chemistry and process research to design and develop scalable innovative synthetic processes to novel medicines using stateoftheart technologies such as HTE datarich experimentation continuous processing catalysis and predictive software. This role provides the opportunity to contribute through handson laboratory innovation while guiding technical strategy for early and latestage programs. You will mentor junior scientists lead crossfunctional project direction and represent process chemistry both internally and externally. You will also oversee execution of GMP production batches through technology transfer and campaign oversight. Role ResponsibilitiesLead technical teams to design execute and interpret complex laboratory experiments aimed at route development process optimization and scaleup.
Develop fitforpurpose processes for early and latestage programs ensuring safety robustness and scalability.
Lead authorship of patents publications and regulatory documents.
Apply modern synthetic organic chemistry principles highthroughput experimentation mechanistic insight and datarich methods to accelerate development.
Effectively communicate scientific strategy risks and solutions to project teams leadership and partner functions.
Drive alignment to project timelines and portfolio strategy.
Mentor junior staff and foster an inclusive scientifically rigorous and collaborative environment.
Lead technology transfer and partner interactions to enable external development campaigns.
Build strong stakeholder relationships across process chemistry partner functions and project teams.
Maintain an external technical presence through publications and presentations.
Basic Qualifications
PhD in Organic Chemistry with 8 years of industry experience in pharmaceutical process development including route design scaleup and GMP manufacturing; or a Masters degree with 15 years of relevant experience.
Deep foundational understanding of synthetic organic chemistry reaction mechanisms process development and modern purification and analytical technologies.
Demonstrated scientific impact via peerreviewed publications patents or conference presentations.
Strong communication skills with demonstrated collaborative leadership in cross functional process development teams.
Experience supporting development from preclinical through commercial stages.
Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.
This is an onsite role (5 days/week).
Submission of a research summary is required.
Preferred Qualifications
Experience developing druglinkers for ADCs PROTACS DACs or other targeted mixedmodality therapeutics.
Experience mentoring and developing scientific staff.
Experience with technology transfer and oversight of external development work.
Experience at innovator pharmaceutical companies strongly preferred.
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers develop and coach others oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name address and the type of payments or other value received generally for public disclosure. Subject to further legal review and statutory or regulatory clarification which Pfizer intends to pursue reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse your name address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race color religion sex sexual orientation age gender identity or gender expression national origin disability or veteran status. Pfizer also complies with all applicable national state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and DevelopmentRequired Experience:
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